Salmon jobs
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Excessive turnover. Employees can often see a failing business more readily than the owner. The sign that this may be the case is an unforeseen exodus by multiple employees at the same time. If this seems to be the case, ask in exit interviews if they have concerns about the long-term viability of the company. Sometimes this could just be a great maneuver by a slick competitor to take your best people or it could also just be a rumor mill that has people running scared about nothing. Find out for yourself with the exit interviews and maybe some department meetings on employee concerns.
Excessive price cuts. If you find yourself slashing prices more than you thought you would, that implies a desperation that may be fatal — if for no other reason than you're cutting into your profit margin.